منابع مشابه
PLEKHA5: A Key to Unlock the Blood-Brain Barrier?
Brain metastases represent a devastating complication of melanoma. Our understanding of the mechanisms driving metastasis to the brain is limited. PLEKHA5 functions as a regulator of brain metastasis in melanoma, and further investigation is warranted to explore the use of PLEKHA5 as a potential therapeutic target.
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It’s an oft-repeated phrase: Two heads are better than one. Likewise, the AAFP has found that when developing clinical practice guidelines, 2 organizations are often better than one. In fact, of the last 9 AAFP clinical practice guidelines, 8 involved other organizations. What does this trend toward collaboration mean? “We’re leaders,” states AAFP Scientifi c Activities Division Director Herber...
متن کاملTarget fishing: a key to unlock the One-To-Many puzzle in drug discovery
The past two decades have marked significant advancements in the field of drug design and development. With the emergence of more sophisticated experimental techniques, advanced computational methods and complementary technologies the current drug development cycle is optimized for drug fishing [1-4] Meaning that, all current efforts are maximized toward the search (and/or design) for more pote...
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The current obesity epidemic and lack of efficient therapeutics demand a clear understanding of the mechanism underlying body weight regulation. Despite intensive research focus on obesity pathogenesis, an effective therapeutic strategy to treat and cure obesity is still lacking. Exciting studies in last decades have established the importance of hypothalamic agouti-related protein-expressing n...
متن کاملSearching for a Toxic Key to Unlock the Mystery of Anemonefish and Anemone Symbiosis
Twenty-six species of anemonefish of the genera Amphiprion and monospecific Premnas, use only 10 species of anemones as hosts in the wild (Families: Actiniidae, Stichodactylidae and Thalassianthidae). Of these 10 anemone species some are used by multiple species of anemonefish while others have only a single anemonefish symbiont. Past studies have explored the different patterns of usage betwee...
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ژورنال
عنوان ژورنال: Nature
سال: 2012
ISSN: 0028-0836,1476-4687
DOI: 10.1038/482143a